Because of these side effects, laboratory monitoring of complete blood counts and liver function tests Sulfasalazine helps to reduce joint pain, swelling, and stiffness
If you are worried, speak to your rheumatology team
levels of folic acid
and various other undesirable effects
The mechanism of action of sulfasalazine remains uncertain
Less common side effects included urticaria, fever, Heinz body anemia, hemolytic anemia, and cyanosis
Concomitant folic acid supplementation is advised because SSZ reduces Primidone — levels may be reduced if taken concurrently with folic acid
Sulfasalazine (salicylazosulfapyridine), an agent widely used for the treatment of ileitis and colitis, is also a competitive inhibitor of intestinal folate transport (1, 2)
Folic Acid Deficiency / chemically induced*
This medication helps reduce pain, swelling, and stiffness associated with arthritis
Interaction of sulfasalazine with reduced folate carrier, the dominant cell membrane transporter for natural folates and methotrexate, may limit the efficacy of combination therapy in patients with rheumatoid arthritis
Sulfasalazine Pregnancy Warnings
Breast feeding Breast feeding For sulfasalazine
Adequate fluid intake must be maintained in order to prevent crystalluria and stone formation
Sulfasalazine may interfere with the absorption of folic acid (one of the B vitamins) from the diet
Oral sulfasalazine inhibits the absorption and metabolism of folic acid and may cause folic acid deficiency (see section 4
It can also be used to treat other diseases such as psoriatic arthritis, Crohn's disease and ulcerative colitis
Sulfasalazine has been shown to actively inhibit the absorption and metabolism of folic acid, which may result in folic acid deficiency
Currently, Folic acid is recommended during pregnancy to reduce the risk of neural tube defects in patients taking folate antagonists; Folic acid given at a dose of 1mg daily does not diminish the efficacy of methotrexate and is routinely given with methotrexate to decrease these side effects
g
Folate is found mainly in dark green leafy vegetables, beans, peas and nuts
Talk to your doctor if you have any questions or concerns
Mean folate absorption, measured using micrograms/kg body weight of Tell your doctor if you are pregnant
Reduced absorption of folic acid and digoxin have been reported when those agents were administered concomitantly with sulfasalazine
6 Fertility, Pregnancy and Lactation, Use in pregnancy)
Publication types Case Reports Letter Folic Acid Deficiency / complications Humans Sulfasalazine / adverse effects* In Reply
Sulfasalazine inhibits folate absorption Nutr Rev
1753-4887
The clinical significance of these interactions has not been established
Sulfasalazine is predicted to decrease the absorption of Folic acid
For maximal tumor-targeting, both folic acid (FA) and lactobionic acid (LA) were coupled to the surface of Sulfasalazine will help you most if you have problems in your arm and leg joints, too
Drug/Laboratory Test Interactions: Several reports of possible interference with measurements, by liquid chromatography, of urinary normetanephrine causing a false-positive test result have been observed in Sulfasalazine works by reducing irritation and swelling in the large intestines
Side effects — The major side effects of sulfasalazine can be classified according to how
Generic name: sulfasalazine
—The findings that sulfasalazine inhibits folate transport, inhibits the hydrolysis of polyglutamyl folate, and decreases the absorption of both polyglutamyl and
This medication does not cure this condition, but it helps decrease symptoms such as fever, stomach Sulfasalazine can affect your folic acid levels
Chemical structures of tetrahydrofolic acid and two antifolates: methotrexate (classical antifolate) and sulfacetamide (non-classical antifolate), commonly
Pharmacology
Serious side effects of
The simultaneous administration of sulfasalazine and folic acid is regular practice in the therapy of inflammatory bowel diseases in order to maintain sufficient folate concentration in patients
Check with your doctor to make Folate deficiency has also been linked to an increased risk for colon cancer
A folic acid supplement of 1000 micrograms (1 milligram) a day is often recommended for those most at risk of folate deficiency
Breast feeding Breast feeding For sulfasalazine
Adequate fluid intake must be maintained in order to prevent crystalluria and stone formation
Sulfasalazine may interfere with the absorption of folic acid (one of the B vitamins) from the diet
Sulfasalazine is an aminosalicylate primarily used in the treatment of rheumatoid arthritis and ulcerative colitis
Oral sulfasalazine inhibits the absorption and metabolism of folic acid and may cause folic acid deficiency (see section 4
Some patients complain of headache, fatigue, and feeling “wiped out” (also called methotrexate “fog”)
The effect that sulfasalazine has on an unborn child has not been studied extensively; Sulfasalazine should only be used during pregnancy if clearly needed; Folic acid is recommended during pregnancy to reduce the risk of neural tube defects in patients taking folate antagonists; Sulfapyridine does pass into breast milk and could affect a Sulfasalazine has been in use for decades as a disease-modifying antirheumatic drug
Sulfasalazine should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity
1981 Jun;22 (6):456-61